in chronic renal failure requires correction dosing regimen: the creatinine clearance of 10-20 ml / min administered in / in or / m to 0.75 g of 2 times a day, with a creatinine clearance less than 10 mL / min – 0.75 g for 1 time per day.
Patients in the continuous hemodialysis anadrol cycle using arteriovenous shunt or hemofiltration a high speed , appoint 0.75 g 2 times a day; for patients on hemofiltration low speed, prescribe the dose recommended under impaired renal function.
The preparation of the slurry and the solution for parenteral administration. Intramuscular – to 0.75 g (bottle of 10 ml) was added 3 mL of water for injection, to 1.5 g (vial 20 mL), add 6 ml. intravenous – to the 0.75 g (vial 10 ml) was added 9 ml water for injection (administered 8 ml) to 1.5 g (vial 20 ml) add 14 ml. In the case of short-term intravenous infusion (for example, up to 30 min) 1.5 g dissolved in 50 ml of water for injection. These solutions can be administered directly into a vein or drip when parenterally administered fluids to the patient.
Side effects : Allergic reactions: fever, rash, pruritus, urticaria, rarely erythema multiforme, bronchospasm, Stevens-Johnson syndrome, anaphylactic shock. From the digestive system: diarrhea, nausea, vomiting or constipation, bloating, cramping and abdominal pain, ulceration oral cavity, oral candidiasis, glossitis, pseudomembranous enterocolitis, liver dysfunction (increased activity of “liver” enzymes in the plasma – aspartate anadrol cycle aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, bilirubin), cholestasis. With the genitourinary system: renal dysfunction (decrease creatinine clearance, increased creatinine and residual nitrogen urea in the blood), dysuria, itching in the perineum, vaginitis. From the side of hematopoiesis: decrease in Hb and hematocrit, anemia (aplastic or hemolytic), eosinophilia, neutropenia, leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia , prothrombin time extension. Local reactions: irritation, infiltration and pain at the injection site, phlebitis.
Overdose Symptoms: CNS stimulation, seizures. Treatment: the appointment of anticonvulsants, providing ventilation and perfusion, monitoring and maintenance of vital body functions, hemodialysis and peritoneal dialysis.
Interaction with other drugs
Simultaneous oral administration of diuretics slows channel secretion and reduces the renal clearance, increases the concentration in plasma and increases of cefuroxime.
While the use of aminoglycosides and diuretics increased risk of nephrotoxic effects.
Drugs that reduce gastric acidity, reduce the anadrol cycle absorption of cefuroxime and bioavailability.
Pharmaceutically compatible with metronidazole, azlocillin, xylitol from aqueous solutions containing 1% lidocaine hydrochloride, 0.9% sodium chloride, 5% dextrose, 0.18% chloride and 4% sodium solution, dextrose solution, 5 % dextrose and 0.9% sodium chloride solution, 5% dextrose and 0.45% sodium chloride, 5% dextrose, and 0.225%) sodium chloride solution, 10% dextrose; 10% inverted sugar in water for injection, Ringer’s solution, sodium lactate solution, Hartmann, 0.9% sodium chloride solution, 5% dextrose and hydrocortisone, heparin (10 U / ml and 50 U / ml) in 0.9% sodium chloride solution , potassium chloride (10 mEq / l and 40 mEq / l) in 0.9% sodium chloride solution.
Pharmaceutically compatible with aminoglycosides, sodium bicarbonate 2.74%.
Patients who had a history of allergic reaction to penicillin, may have hypersensitivity to cephalosporin antibiotics. During treatment requires monitoring of renal function, especially in patients receiving the drug in high doses. The treatment is recommended to continue for 48-72 hours after the disappearance of symptoms, in the case of infections caused by Streptococcus pyogenes, it is recommended to continue treatment for at least 10 days.
During treatment possible false-positive direct anadrol cycletest and false positive reaction on urine glucose.
After dilution can be stored at room temperature for 7 hours in the refrigerator -. 48 hours is allowed to use yellowed during storage solution.
during the treatment can not use ethanol.
patients receiving cefuroxime in determining blood glucose levels is recommended to use tests with glucose oxidase or hexokinase.
in background treatment of meningitis in children is possible hearing loss.
in the transition from parenteral to the reception inside should take into account the severity of the infection, sensitivity of micro-organisms and the general condition of the patient. If after 72 hours after administration of cefuroxime into the clinical improvement is not observed, it is necessary to continue the parenteral administration.
Powder for solution for intravenous and intramuscular injection of 0.75 g and 1.5 g in bottles of 10 and 20 ml.
1, 5, or 10 vials with the instructions for use are placed in a pile of cardboard. 50 vials of 1-5 instructions for use are placed in a box made of cardboard for delivery in hospitals.