Deposited mainly in the liver.
Relationship to plasma proteins – 90%. The maximum concentration after subcutaneous and intramuscular administration anadrol results-. 1 h
From liver excreted in the bile into the intestine and re-absorbed into the bloodstream. Displayed with normal renal function – 7.10% kidneys, about 50% – the faeces; with reduced kidney function – 0-7% by the kidneys, 70 100% – with the feces. It penetrates through the placental barrier, breast milk.
State, accompanied by a deficiency of vitamin B 12 :
Chronic anemia occurring with the deficiency of vitamin B 12 (Addison-Birmera disease, alimentary macrocytic anemia), in the complex therapy of anemia (including iron deficiency, post-hemorrhagic, aplastic anemia, caused by toxic substances and / or the JIC). in the treatment of : chronic hepatitis, cirrhosis, liver failure, alcoholism. in neurology : polyneuritis, radiculitis, malnutrition, neuralgia (including trigeminal neuralgia), funicular myelosis, peripheral disease nervously:;System traumatic genesis, amyotrophic lateral sclerosis, cerebral palsy, Down syndrome. In dermatology : psoriasis, photo dermatosis, dermatitis herpetiformis, atopic dermatitis. For prophylaxis – the appointment of biguanides, Pasco, ascorbic acid in high doses, disease anadrol results of the stomach and intestine malabsorption of vitamin B 12 (resection of the stomach, small intestine, Crohn’s disease, sprue, sprue), enteritis, diarrhea, radiation sickness.
Hypersensitivity to the drug, thromboembolism, erythremia, polycythemia, pregnancy (there are some indications of a possible teratogenic effect in high doses), lactation.
angina, benign and malignant tumors, accompanied by megaloblastic anemia and deficiency of vitamin B 12 , the tendency to form blood clots.
Dosing and Administration
The drug is administered subcutaneously, intramuscularly, intravenously and intralyumbalno.
Subcutaneous, anemia every other day; when funicular myelosis, makrotsitarnyh anemia in violation of the nervous system – at 400-500 mg / day in the first week – every day, then the intervals between injections to 5-7 days (at the same time prescribe folic acid); in remission maintenance dose -100 mg / day, 2 times a month, and in violation of 200-400 nervous system function g 2-4 times a month.
In the acute post-hemorrhagic anemia and iron – 30-100 mg 2-3 times a week ; with aplastic anemia – 100 micrograms before clinical and hematologic improvement. When violations of the nervous system – at 200-400 mcg 2-4 times a anadrol results month.
In diseases of the central nervous system and peripheral nervous system – at 200-500 mcg every other day for 2 weeks.
In diseases of the peripheral nervous system of traumatic origin – 200-400 mcg every other day for 40-45 days.
When hepatitis and cirrhosis of the liver – 30-60 mg / day or 100 mg every other day for 25-40 days.
When radiation sickness – by 60-100 mg daily for 20-30 days . When funicular myelosis, amyotrophic lateral sclerosis -. Intralyumbalno, 15-30 mg, with a gradual increase in dose to 200 to 250 mcg per injection
to eliminate deficiency is introduced into / m or / in at 1 mg daily for 1 . 2 weeks
early age children with nutritional anemia and premature babies – subcutaneous 30 mg a day every day for 15 days. When dystrophy in young children, Down syndrome and cerebral palsy – subcutaneously, 15-30 micrograms a day.